Small oil and gas producers, however, are worried that the new rules will create onerous burdens that will put them out of business.
The proposed regulations could take time to put in place, are likely to face legal challenges and could be reversed by a future administration, observers say.
“As a president tries to use unilateral executive powers, there are immediately a set of hurdles,” said Barry Rabe, a professor of environmental policy at the University of Michigan. “It’s not going to be an easy transition.”
In addition to reducing greenhouse gases, regulating methane will protect public health, E.P.A. officials said.
When methane is released into the atmosphere, it is frequently accompanied by hazardous chemicals like benzene and hydrogen sulfide. Exposure to those pollutants has been linked to serious health problems including asthma and cancer.
Sue Franklin knows the effects firsthand. She and her husband, Jim, used to live in the West Texas town of Verhalen, where oil and gas drilling operations took off around 2014.
Gases leaked from two new wells and gave the couple headaches, nosebleeds and asthma attacks.
The Franklins eventually moved about 40 miles away, but Ms. Franklin, 70, said she feared she would have respiratory problems for the rest of her life.